WHO (World Health Organisation) give a definition for Health (The first state) that being perfect condition of physical, mental and social contact, patients are second state. The third state is a middle process between Health and illness who feeling weakness, fatigue, no appetite, insomnia, listless, but no evidence third state may transform into Health State after corrective handling or becoming illness in opposite.

The causes from multiple factor, physical and mental over-withdraw inducing overtire, natural aged, the preceding stage of cardiovascular, cerebrovascular and other chronic disease, convalescent of operation, hypothermic period of biological clock etc.

In TCM works, this problem is basically due to congenital defect and the pathogenic factors damage to Qi and blood. Exogenous pathogenic factors encompass atmospheric changes, pestilential pathogens and trauma. Endogenous pathogenic factors are generally emotional factor (joy, anger, melancholy, anxiety, grief, fear and fright), improper diet, fatigue and over-indulgence in sex. Bad mood is main cause of disease, sometime can inducing sudden death.

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